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Acne; breast tenderness or enlargement; changes in appetite; changes in sexual interest; changes in weight; dizziness; hair loss; headache; nausea; stomach cramps or bloating; unusual spotting or bleeding; vomiting.
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In the male body, an abundant supply of testosterone combines with a plentiful enzyme called aromatase to produce estrogen when and where it is needed.
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OH-E 2 is thought to be the most carcinogenic of all the estradiol metabolites, especially considering that CYP1B1 exhibits overexpression in breast cancer tumors.
It is the only estrogen that is present in any amount in women after menopause.
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Estrogen hormones play an essential role in the growth and development of female secondary sexual characteristics such as breasts, pubic and armpit hair, endometrium, regulation of the menstrual cycle and the reproductive system.
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